![]() There is a possibility for serious adverse reactions in nursing infants from sulfonamides. Sulfonamides are known to be excreted in human milk and all sulfonamide derivatives are known to increase the possibility of kernicterus. Fifty-nine studies were included in this qualitative analysis. A detailed qualitative analysis of published articles was performed to evaluate the evidence for the use of silver in infected wounds, clean wounds, burns, and over closed surgical incisions. See references Silver sulfadiazine topical Breastfeeding WarningsĪ decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.Įxcreted into animal milk: Data not availableĬomments: The effects in the nursing infant are unknown. A search of high-quality studies on the use of silver in wound care was performed on PubMed. SILVADENE Cream 1 (silver sulfadiazine) is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns. According to some authorities: Use should be avoided during the last month of pregnancy. Use is not recommended unless clearly needed, especially in pregnant women approaching or at term. US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. Accompanying texts should be consulted for further details. There are no controlled data in human pregnancy.ĪU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. Sulfonamides may cause kernicterus in patients during the first month of life by displacing bilirubin from plasma albumin. Silver sulfadiazine topical Pregnancy WarningsĪnimal studies have failed to reveal evidence of fetal harms. Silver sulfadiazine topical Pregnancy and Breastfeeding Warningsīrand names: SSD, SSD AF, Silvadene, Silvadene Cream 1%, Thermazene Silver Sulfadiazine Cream 1, a sulfa drug, is used to prevent and treat infections of second and third degree burns.
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